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Double-Mutant Cycle Scanning of the Interaction of a Peptide Ligand and its G Protein-Coupled Receptor

The interaction between the yeast G protein coupled receptor (GPCR), Ste2p, and its α-factor tridecapeptide ligand was subjected to double-mutant cycle scanning analysis by which the pairwise interaction energy of each ligand residue with two receptor residues, N205 and Y266, was determined. The mut...

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Bibliografiska uppgifter
Huvudupphovsmän: Naider, Fred, Becker, Jeffrey M., Lee, Yong–Hun, Horovitz, Amnon
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2007
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2590777/
https://ncbi.nlm.nih.gov/pubmed/17298081
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi602415u
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