Albumin-conjugated C34 Peptide HIV-1 Fusion Inhibitor: EQUIPOTENT TO C34 AND T-20 IN VITRO WITH SUSTAINED ACTIVITY IN SCID-HU THY/LIV MICE

Entry inhibitors of human immunodeficiency virus, type 1 (HIV-1) have been the focus of much recent research. C34, a potent fusion inhibitor derived from the HR2 region of gp41, was engineered into a 1:1 human serum albumin conjugate through stable covalent attachment of a maleimido-C34 analog onto...

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Detalhes bibliográficos
Main Authors: Stoddart, Cheryl A., Nault, Geneviève, Galkina, Sofiya A., Thibaudeau, Karen, Bakis, Peter, Bousquet-Gagnon, Nathalie, Robitaille, Martin, Bellomo, Maryanne, Paradis, Véronique, Liscourt, Patricia, Lobach, Alexandra, Rivard, Marie-Ève, Ptak, Roger G., Mankowski, Marie K., Bridon, Dominique, Quraishi, Omar
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2008
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2590714/
https://ncbi.nlm.nih.gov/pubmed/18809675
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M805536200
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