Potent Activity of the HIV-1 Maturation Inhibitor Bevirimat in SCID-hu Thy/Liv Mice

BACKGROUND: The HIV-1 maturation inhibitor, 3-O-(3′,3′-dimethylsuccinyl) betulinic acid (bevirimat, PA-457) is a promising drug candidate with 10 nM in vitro antiviral activity against multiple wild-type (WT) and drug-resistant HIV-1 isolates. Bevirimat has a novel mechanism of action, specifically...

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Main Authors: Stoddart, Cheryl A., Joshi, Pheroze, Sloan, Barbara, Bare, Jennifer C., Smith, Philip C., Allaway, Graham P., Wild, Carl T., Martin, David E.
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2007
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2080775/
https://ncbi.nlm.nih.gov/pubmed/18043758
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0001251
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