Nanoscale Increases in CD2-CD48-mediated Intermembrane Spacing Decrease Adhesion and Reorganize the Immunological Synapse

The relationship between intermembrane spacing, adhesion efficiency, and lateral organization of adhesion receptors has not been established for any adhesion system. We have utilized the CD2 ligand CD48 with two (wild type CD48 (CD48-WT)), four (CD48-CD2), or five (CD48-CD22) Ig-like domains. CD48-W...

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Hlavní autoři: Milstein, Oren, Tseng, Su-Yi, Starr, Toby, Llodra, Jaime, Nans, Andrea, Liu, Mengling, Wild, Martin K., van der Merwe, P. Anton, Stokes, David L., Reisner, Yair, Dustin, Michael L.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2008
Témata:
Membrane Transport, Structure, Function, and Biogenesis
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2590684/
https://ncbi.nlm.nih.gov/pubmed/18826951
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M804756200
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