Nanoscale Increases in CD2-CD48-mediated Intermembrane Spacing Decrease Adhesion and Reorganize the Immunological Synapse

The relationship between intermembrane spacing, adhesion efficiency, and lateral organization of adhesion receptors has not been established for any adhesion system. We have utilized the CD2 ligand CD48 with two (wild type CD48 (CD48-WT)), four (CD48-CD2), or five (CD48-CD22) Ig-like domains. CD48-W...

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Detalhes bibliográficos
Main Authors: Milstein, Oren, Tseng, Su-Yi, Starr, Toby, Llodra, Jaime, Nans, Andrea, Liu, Mengling, Wild, Martin K., van der Merwe, P. Anton, Stokes, David L., Reisner, Yair, Dustin, Michael L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2008
Assuntos:
Membrane Transport, Structure, Function, and Biogenesis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2590684/
https://ncbi.nlm.nih.gov/pubmed/18826951
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M804756200
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