Construction of minitransposons for constitutive and inducible expression of pertussis toxin in bvg-negative Bordetella bronchiseptica.

Appropriately detoxified pertussis toxin (PT) of Bordetella pertussis is considered to be an essential component of new-generation whooping cough vaccines, but the development of a procedure to obtain high levels of purified toxin has been and continues to be a major difficulty. To produce a system...

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Pubblicato in:	Infect Immun
Autori principali:	Walker, M J, Rohde, M, Wehland, J, Timmis, K N
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 1991
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC259022/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1682257/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/iai.59.11.4238-4248.1991
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