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Association Rate Constants of Ras-Effector Interactions Are Evolutionarily Conserved

Evolutionary conservation of protein interaction properties has been shown to be a valuable indication for functional importance. Here we use homology interface modeling of 10 Ras-effector complexes by selecting ortholog proteins from 12 organisms representing the major eukaryotic branches, except p...

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Détails bibliographiques
Auteurs principaux: Kiel, Christina, Aydin, Dorothee, Serrano, Luis
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2008
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2588540/
https://ncbi.nlm.nih.gov/pubmed/19096503
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1000245
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