Elucidation of the mode of interaction in the UP1–telomerase RNA–telomeric DNA ternary complex which serves to recruit telomerase to telomeric DNA and to enhance the telomerase activity

We found that UP1, a proteolytic product of heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1), both enhances and represses the telomerase activity. The formation of the UP1–telomerase RNA–telomeric DNA ternary complex was revealed by a gel retardation experiment. The interactions in the ternary...

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Dettagli Bibliografici
Autori principali: Nagata, Takashi, Takada, Yusuke, Ono, Asami, Nagata, Kayoko, Konishi, Yuki, Nukina, Takeshi, Ono, Manami, Matsugami, Akimasa, Furukawa, Ayako, Fujimoto, Natsuki, Fukuda, Hirokazu, Nakagama, Hitoshi, Katahira, Masato
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2008
Soggetti:
Structural Biology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2588520/
https://ncbi.nlm.nih.gov/pubmed/18953025
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkn767
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