Thyroid-Specific Enhancer-Binding Protein/NKX2.1 Is Required for the Maintenance of Ordered Architecture and Function of the Differentiated Thyroid

Thyroid-specific enhancer-binding protein (T/ebp)/Nkx2.1-null mouse thyroids degenerate by embryonic day (E) 12–13 through apoptosis whereas T/ebp/Nkx2.1-heterogyzgous mice exhibit hypothyroidism with elevated TSH levels. To understand the role of T/ebp/Nkx2.1 in the adult thyroid, a thyroid follicu...

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Main Authors: Kusakabe, Takashi, Kawaguchi, Akio, Hoshi, Nobuo, Kawaguchi, Rumi, Hoshi, Sayuri, Kimura, Shioko
格式: Artigo
語言:Inglês
出版: 2006
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2588428/
https://ncbi.nlm.nih.gov/pubmed/16601074
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/me.2005-0327
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