Potent and nontoxic antisense oligonucleotides containing locked nucleic acids

Insufficient efficacy and/or specificity of antisense oligonucleotides limit their in vivo usefulness. We demonstrate here that a high-affinity DNA analog, locked nucleic acid (LNA), confers several desired properties to antisense agents. Unlike DNA, LNA/DNA copolymers were not degraded readily in b...

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Hauptverfasser: Wahlestedt, Claes, Salmi, Peter, Good, Liam, Kela, Johanna, Johnsson, Thomas, Hökfelt, Tomas, Broberger, Christian, Porreca, Frank, Lai, Josephine, Ren, Kunkun, Ossipov, Michael, Koshkin, Alexei, Jakobsen, Nana, Skouv, Jan, Oerum, Henrik, Jacobsen, Mogens Havsteen, Wengel, Jesper
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2000
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC25880/
https://ncbi.nlm.nih.gov/pubmed/10805816
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