Potent and nontoxic antisense oligonucleotides containing locked nucleic acids

Insufficient efficacy and/or specificity of antisense oligonucleotides limit their in vivo usefulness. We demonstrate here that a high-affinity DNA analog, locked nucleic acid (LNA), confers several desired properties to antisense agents. Unlike DNA, LNA/DNA copolymers were not degraded readily in b...

Полное описание

Библиографические подробности

Опубликовано в::	Proc Natl Acad Sci U S A
Главные авторы:	Wahlestedt, Claes, Salmi, Peter, Good, Liam, Kela, Johanna, Johnsson, Thomas, Hökfelt, Tomas, Broberger, Christian, Porreca, Frank, Lai, Josephine, Ren, Kunkun, Ossipov, Michael, Koshkin, Alexei, Jakobsen, Nana, Skouv, Jan, Oerum, Henrik, Jacobsen, Mogens Havsteen, Wengel, Jesper
Формат:	Artigo
Язык:	Inglês
Опубликовано:	National Academy of Sciences 2000
Предметы:	Biological Sciences
Online-ссылка:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC25880/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10805816/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.97.10.5633
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