Non-DNA-binding platinum anticancer agents: Cytotoxic activities of platinum–phosphato complexes towards human ovarian cancer cells

DNA is believed to be the molecular target for the cytotoxic activities of platinum (Pt) anticancer drugs. We report here a class of platinum(II)- and platinum(IV)-pyrophosphato complexes that exhibit cytotoxicity comparable with and, in some cases, better than cisplatin in ovarian cell lines (A2780...

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Detalhes bibliográficos
Main Authors: Bose, Rathindra N., Maurmann, Leila, Mishur, Robert J., Yasui, Linda, Gupta, Shefalika, Grayburn, W. Scott, Hofstetter, Heike, Salley, Tara
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2008
Assuntos:
Physical Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2587608/
https://ncbi.nlm.nih.gov/pubmed/19020081
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0803094105
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