Anti-VEGF agents confer survival advantages to tumor-bearing mice by improving cancer-associated systemic syndrome

The underlying mechanism by which anti-VEGF agents prolong cancer patient survival is poorly understood. We show that in a mouse tumor model, VEGF systemically impairs functions of multiple organs including those in the hematopoietic and endocrine systems, leading to early death. Anti-VEGF antibody,...

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Bibliografiske detaljer
Main Authors: Xue, Yuan, Religa, Piotr, Cao, Renhai, Hansen, Anker Jon, Lucchini, Franco, Jones, Bernt, Wu, Yan, Zhu, Zhenping, Pytowski, Bronislaw, Liang, Yuxiang, Zhong, Weide, Vezzoni, Paolo, Rozell, Björn, Cao, Yihai
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2008
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2587583/
https://ncbi.nlm.nih.gov/pubmed/19017793
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0807967105
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