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Stepwise evolution of protein native structure with electrospray into the gas phase, 10(−12) to 10(2) s

Mass spectrometry (MS) has been revolutionized by electrospray ionization (ESI), which is sufficiently “gentle” to introduce nonvolatile biomolecules such as proteins and nucleic acids (RNA or DNA) into the gas phase without breaking covalent bonds. Although in some cases noncovalent bonding can be...

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Autori principali: Breuker, Kathrin, McLafferty, Fred W.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2008
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2587555/
https://ncbi.nlm.nih.gov/pubmed/19033474
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0807005105
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