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Orthogonal Pd- and Cu-Based Catalyst Systems for the C- and N-Arylation of Oxindoles

In the cross-coupling reactions of unprotected oxindoles with aryl halides, Pd- and Cu-based catalyst systems displayed orthogonal chemoselectivity. A Pd/dialkylbiarylphosphine-based catalyst system chemoselectively arylated oxindole at the 3-position, while arylation occurred exclusively at the nit...

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Detalhes bibliográficos
Main Authors: Altman, Ryan A., Hyde, Alan M., Huang, Xiaohua, Buchwald, Stephen L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2587375/
https://ncbi.nlm.nih.gov/pubmed/18588302
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja803179s
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