Alternative (M2) activation of Kupffer cells by PPARδ ameliorates obesity-induced insulin resistance

Macrophage infiltration and activation in metabolic tissues underlie obesity-induced insulin resistance and type 2 diabetes. While inflammatory activation of resident hepatic macrophages potentiates insulin resistance, the functions of alternatively activated Kupffer cells in metabolic disease remai...

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Autori principali: Odegaard, Justin I., Ricardo-Gonzalez, Roberto R., Eagle, Alex Red, Vats, Divya, Morel, Christine R., Goforth, Matthew H., Subramanian, Vidya, Mukundan, Lata, Ferrante, Anthony W., Chawla, Ajay
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2008
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2587370/
https://ncbi.nlm.nih.gov/pubmed/18522831
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2008.04.003
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