Overexpression of the zinc uptake transporter hZIP1 inhibits NF-κB and reduces the malignant potential of prostate cancer cells in vitro and in vivo

PURPOSE: Intracellular zinc levels and expression of the zinc uptake transporter, hZIP1, are markedly down-regulated in prostate adenocarcinomatous tissue compared with normal prostate tissue. Our previous studies have demonstrated that zinc inhibits NF-κB activity and reduces the malignant potentia...

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Autores principales: Golovine, Konstantin, Makhov, Peter, Uzzo, Robert G., Shaw, Tavis, Kunkle, David, Kolenko, Vladimir M.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2008
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2587298/
https://ncbi.nlm.nih.gov/pubmed/18765529
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-08-0455
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