Role of the Multifunctional DNA Repair and Redox Signaling Protein Ape1/Ref-1 in Cancer and Endothelial Cells: Small-Molecule Inhibition of the Redox Function of Ape1

The DNA base excision-repair pathway is responsible for the repair of DNA damage caused by oxidation/alkylation and protects cells against the effects of endogenous and exogenous agents. Removal of the damaged base creates a baseless (AP) site. AP endonuclease1 (Ape1) acts on this site to continue t...

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Autores principales: Luo, Meihua, Delaplane, Sarah, Jiang, Aihua, Reed, April, He, Ying, Fishel, Melissa, Nyland, Rodney L., Borch, Richard F., Qiao, Xiaoxi, Georgiadis, Millie M., Kelley, Mark R.
Formato: Artigo
Lenguaje:Inglês
Publicado: Mary Ann Liebert, Inc. 2008
Materias:
Forum Original Research Communication
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2587278/
https://ncbi.nlm.nih.gov/pubmed/18627350
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/ars.2008.2120
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