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An ENU-induced mutation in the lymphotoxin α gene impairs lymph organogenesis of lymphoid tissues in C57BL/6 mice

The TNF family is critical for development of lymphoid organs and plays significant roles in regulation of innate and adoptive immune responses. Here we describe a novel N-ethyl-N-nitrosourea (ENU)-induced mutant strain, HLB382, with a point mutation in the Lta gene, which encodes lymphotoxin (LT) α...

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Détails bibliographiques
Auteurs principaux: Wanga, Hongsheng, Fenga, Jianxun, Qi, Chenfeng, Morse, Herbert C.
Format: Artigo
Langue:Inglês
Publié: 2008
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2587207/
https://ncbi.nlm.nih.gov/pubmed/18384745
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2008.03.118
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