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Ca(2+)/calmodulin-mediated fast desensitization by the B1b subunit of the CNG channel affects response termination but not sensitivity to recurring stimulation in olfactory sensory neurons

Ca(2+)/calmodulin-mediated negative feedback is a prototypical regulatory mechanism for Ca(2+) permeable ion channels. In olfactory sensory neurons (OSNs) such regulation on the cyclic nucleotide-gated (CNG) channel is considered a major mechanism of OSN adaptation. To determine the role of Ca(2+)/c...

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Detalhes bibliográficos
Main Authors: Song, Yijun, Cygnar, Katherine D., Sagdullaev, Botir, Valley, Matthew, Hirsh, Sarah, Stephan, Aaron, Reisert, Johannes, Zhao, Haiqing
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2587172/
https://ncbi.nlm.nih.gov/pubmed/18466748
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2008.02.029
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