Cortical cell death induced by IL-1 is mediated via actions in the hypothalamus of the rat

The cytokine IL-1 mediates diverse forms of neurodegeneration, but its mechanism of action is unknown. We have demonstrated previously that exogenous and endogenous IL-1 acts specifically in the rat striatum to dramatically enhance ischemic and excitotoxic brain damage and cause extensive cortical i...

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Bibliographic Details
Main Authors: Allan, Stuart M., Parker, Lisa C., Collins, Barry, Davies, Ralph, Luheshi, Giamal N., Rothwell, Nancy J.
Format: Artigo
Language:Inglês
Published: The National Academy of Sciences 2000
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC25871/
https://ncbi.nlm.nih.gov/pubmed/10779559
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