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Cutting Edge: Viral Infection Breaks NK Cell Tolerance to “Missing Self”

NK cells attack cells lacking MHC class I, yet MHC class I-deficient mice have normal numbers of NK cells with intact, albeit diminished, functions. Moreover, wild-type NK cells are tolerant of MHC class I-deficient cells in mixed bone marrow chimeras. Here, we investigated how the absence of MHC cl...

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Sonraí Bibleagrafaíochta
Main Authors: Sun, Joseph C., Lanier, Lewis L.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2008
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2587071/
https://ncbi.nlm.nih.gov/pubmed/19017932
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