Type I IFN promotes NK cell expansion during viral infection by protecting NK cells against fratricide

Type I interferon (IFN) is crucial in host antiviral defense. Previous studies have described the pleiotropic role of type I IFNs on innate and adaptive immune cells during viral infection. Here, we demonstrate that natural killer (NK) cells from mice lacking the type I IFN-α receptor (Ifnar(−/−)) o...

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Sparad:
Bibliografiska uppgifter
I publikationen:J Exp Med
Huvudupphovsmän: Madera, Sharline, Rapp, Moritz, Firth, Matthew A., Beilke, Joshua N., Lanier, Lewis L., Sun, Joseph C.
Materialtyp: Artigo
Språk:Inglês
Publicerad: The Rockefeller University Press 2016
Ämnen:
Research Articles
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4749923/
https://ncbi.nlm.nih.gov/pubmed/26755706
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20150712
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