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Defining the Pathway for Tat-mediated Delivery of β-Glucuronidase in Cultured Cells and MPS VII Mice

We used recombinant forms of human β-glucuronidase (GUS) purified from secretions from stably transfected CHO cells to compare the native enzyme to a GUS-Tat C-terminal fusion protein containing the 11-amino-acid HIV Tat protein transduction domain for: (1) susceptibility to endocytosis by cultured...

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Bibliografiske detaljer
Main Authors: Orii, Koji O., Grubb, Jeffrey H., Vogler, Carole, Levy, Beth, Tan, Yun, Markova, Kamelia, Davidson, Beverly L., Mao, Q., Orii, Tadao, Kondo, Naomi, Sly, William S.
Format: Artigo
Sprog:Inglês
Udgivet: 2005
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2587041/
https://ncbi.nlm.nih.gov/pubmed/16043103
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2005.02.031
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