Role of histone deacetylase inhibitor-induced ROS and DNA damage in LAQ-824/fludarabine antileukemic interactions

The role of ROS production on DNA damage and potentiation of fludarabine (F) lethality by the HDAC inhibitor LAQ-824 was investigated in human leukemia cells. Pre-exposure (24 h) of U937, HL-60, Jurkat, or K562 cells to LAQ-824 (40nM) followed by F (0.4µM) dramatically potentiated apoptosis (≥75%)....

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Bibliographic Details
Main Authors: Rosato, Roberto R., Almenara, Jorge A., Maggio, Sonia C., Coe, Stefanie, Atadja, Peter, Dent, Paul, Grant, Steven
Format: Artigo
Language:Inglês
Published: 2008
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2586957/
https://ncbi.nlm.nih.gov/pubmed/18852132
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-08-0385
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