Adipocyte-derived Th2 cytokines and myeloid PPAR delta regulate macrophage polarization and insulin sensitivity

The polarization of adipose tissue resident macrophages towards the alternatively activated, anti-inflammatory M2 phenotype is believed to improve insulin sensitivity. However, mechanisms controlling tissue macrophage activation remain unclear. We show adipocytes are a source of Th2 cytokines, inclu...

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Autori principali: Kang, Kihwa, Reilly, Shannon M., Karabacak, Volkan, Gangl, Matthew R., Fitzgerald, Kelly, Hatano, Ben, Lee, Chih-Hao
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2008
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2586840/
https://ncbi.nlm.nih.gov/pubmed/18522830
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2008.04.002
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