Bmi1 Is Required for Hedgehog Pathway-Driven Medulloblastoma Expansion

Inappropriate Hedgehog (Hh) signaling underlies development of a subset of medulloblastomas, and tumors with elevated HH signaling activity express the stem cell self-renewal gene BMI1. To test whether Bmi1 is required for Hh-driven medulloblastoma development, we varied Bmi1 gene dosage in transgen...

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Detalhes bibliográficos
Main Authors: Michael, Lowell Evan, Westerman, Bart A, Ermilov, Alexandre N, Wang, Aiqin, Ferris, Jennifer, Liu, Jianhong, Blom, Marleen, Ellison, David W, van Lohuizen, Maarten, Dlugosz, Andrzej A
Formato: Artigo
Idioma:Inglês
Publicado em: Neoplasia Press 2008
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2586685/
https://ncbi.nlm.nih.gov/pubmed/19048113
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