Characterization of genetically inactivated pertussis toxin mutants: candidates for a new vaccine against whooping cough.

the introduction of two amino acid substitutions within the enzymatically active subunit S1 of pertussis toxin (PT) abolishes its ADP-ribosyltransferase activity and toxicity on CHO cells (Pizza et al., Science 246:497-500, 1989). These genetically inactivated molecules are also devoid of other in v...

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Autors principals: Nencioni, L, Pizza, M, Bugnoli, M, De Magistris, T, Di Tommaso, A, Giovannoni, F, Manetti, R, Marsili, I, Matteucci, G, Nucci, D
Format: Artigo
Idioma:Inglês
Publicat: 1990
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Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC258625/
https://ncbi.nlm.nih.gov/pubmed/2323818
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