Characterization of genetically inactivated pertussis toxin mutants: candidates for a new vaccine against whooping cough.

the introduction of two amino acid substitutions within the enzymatically active subunit S1 of pertussis toxin (PT) abolishes its ADP-ribosyltransferase activity and toxicity on CHO cells (Pizza et al., Science 246:497-500, 1989). These genetically inactivated molecules are also devoid of other in v...

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Detalhes bibliográficos

Publicado no:	Infect Immun
Principais autores:	Nencioni, L, Pizza, M, Bugnoli, M, De Magistris, T, Di Tommaso, A, Giovannoni, F, Manetti, R, Marsili, I, Matteucci, G, Nucci, D
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1990
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC258625/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2323818/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/iai.58.5.1308-1315.1990
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