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Destabilization of DNA duplexes by oxidative damage at guanine: implications for lesion recognition and repair
We have used molecular dynamics simulations to study the structure and dynamics of a range of DNA duplexes containing the 2,6-diamino-4-hydroxy-5-formamidopyrimidine (FapydG) lesion that can result from oxidative damage at guanine. Compared to the corresponding undamaged DNA duplexes, FapydG-contain...
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| Main Authors: | , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
The Royal Society
2008
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2586096/ https://ncbi.nlm.nih.gov/pubmed/18782724 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1098/rsif.2008.0304.focus |
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