Destabilization of DNA duplexes by oxidative damage at guanine: implications for lesion recognition and repair

We have used molecular dynamics simulations to study the structure and dynamics of a range of DNA duplexes containing the 2,6-diamino-4-hydroxy-5-formamidopyrimidine (FapydG) lesion that can result from oxidative damage at guanine. Compared to the corresponding undamaged DNA duplexes, FapydG-contain...

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Bibliografiset tiedot
Päätekijät: Jiranusornkul, Supat, Laughton, Charles A.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: The Royal Society 2008
Aiheet:
Research Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC2586096/
https://ncbi.nlm.nih.gov/pubmed/18782724
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1098/rsif.2008.0304.focus
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