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ICOS-dependent extrafollicular helper T cells elicit IgG production via IL-21 in systemic autoimmunity
The role of specialized follicular helper T (T(FH)) cells in the germinal center has become well recognized, but it is less clear how effector T cells govern the extrafollicular response, the dominant pathway of high-affinity, isotype-switched autoantibody production in the MRL/MpJ-Fas(lpr) (MRL(lpr...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Rockefeller University Press
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2585848/ https://ncbi.nlm.nih.gov/pubmed/18981236 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20080840 |
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