ICOS-dependent extrafollicular helper T cells elicit IgG production via IL-21 in systemic autoimmunity

The role of specialized follicular helper T (T(FH)) cells in the germinal center has become well recognized, but it is less clear how effector T cells govern the extrafollicular response, the dominant pathway of high-affinity, isotype-switched autoantibody production in the MRL/MpJ-Fas(lpr) (MRL(lpr...

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Auteurs principaux: Odegard, Jared M., Marks, Benjamin R., DiPlacido, Leah D., Poholek, Amanda C., Kono, Dwight H., Dong, Chen, Flavell, Richard A., Craft, Joe
Format: Artigo
Langue:Inglês
Publié: The Rockefeller University Press 2008
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Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2585848/
https://ncbi.nlm.nih.gov/pubmed/18981236
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20080840
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