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Glycogen Synthase Kinase 3 inhibition Induces Glioma Cell Death through c-MYC, NF-κB and Glucose Regulation

Glycogen synthase kinase-3 (GSK3), a serine/threonine kinase, is involved in diverse cellular processes ranging from nutrient and energy homeostasis to proliferation and apoptosis. Its role in glioblastoma multiforme (GBM) has yet to be elucidated. We identified GSK3 as a regulator of GBM cell survi...

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Detalhes bibliográficos
Main Authors: Kotliarova, Svetlana, Pastorino, Sandra, Kovell, Lara C., Kotliarov, Yuri, Song, Hua, Zhang, Wei, Bailey, Rolanda, Maric, Dragan, Zenklusen, Jean Claude, Lee, Jeongwu, Fine, Howard A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2585745/
https://ncbi.nlm.nih.gov/pubmed/18701488
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-08-0850
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