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p53 induces distinct epigenetic states at its direct target promoters

BACKGROUND: The tumor suppressor protein p53 is a transcription factor that is mutated in many cancers. Regulation of gene expression by binding of wild-type p53 to its target sites is accompanied by changes in epigenetic marks like histone acetylation. We studied DNA binding and epigenetic changes...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Vrba, Lukas, Junk, Damian J, Novak, Petr, Futscher, Bernard W
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: BioMed Central 2008
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2585595/
https://ncbi.nlm.nih.gov/pubmed/18922183
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2164-9-486
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