MHC-Dependent Desensitization of Intrinsic Anti-Self Reactivity

The survival of naïve T cells is compromised in the absence of molecules encoded by the major histocompatibility complex (MHC) while antigen-experienced T cells survive. We hypothesized that survival pressures in an in vivo, MHC-deficient environment would permit enrichment of less frequent antigen-...

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Detalhes bibliográficos
Main Authors: Jubala, Cristan M., Lamerato-Kozicki, Angela R., Borakove, Michelle, Lang, Julie, Gardner, Lori A., Coffey, David, Helm, Karen M., Schaack, Jerome, Baier, Monika, Cutter, Gary R., Bellgrau, Donald, Modiano, Jaime F.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2585149/
https://ncbi.nlm.nih.gov/pubmed/18523772
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00262-008-0535-0
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