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Development of selective blockers for Ca(2+)-activated Cl(- )channel using Xenopus laevis oocytes with an improved drug screening strategy

BACKGROUND: Ca(2+)-activated Cl(- )channels (CaCCs) participate in many important physiological processes. However, the lack of effective and selective blockers has hindered the study of these channels, mostly due to the lack of good assay system. Here, we have developed a reliable drug screening me...

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Bibliografski detalji
Glavni autori: Oh, Soo-Jin, Park, Jung Hwan, Han, Sungyu, Lee, Jae Kyun, Roh, Eun Joo, Lee, C Justin
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2008
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2585076/
https://ncbi.nlm.nih.gov/pubmed/18959787
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1756-6606-1-14
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