p16 Mutation Spectrum in the Premalignant Condition Barrett's Esophagus

BACKGROUND: Mutation, promoter hypermethylation and loss of heterozygosity involving the tumor suppressor gene p16 (CDKN2a/INK4a) have been detected in a wide variety of human cancers, but much less is known concerning the frequency and spectrum of p16 mutations in premalignant conditions. METHODS A...

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Autori principali: Paulson, Thomas G., Galipeau, Patricia C., Xu, Lianjun, Kissel, Heather D., Li, Xiaohong, Blount, Patricia L., Sanchez, Carissa A., Odze, Robert D., Reid, Brian J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2008
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2585012/
https://ncbi.nlm.nih.gov/pubmed/19043591
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0003809
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