Lubiprostone activates non-CFTR-dependent respiratory epithelial chloride secretion in cystic fibrosis mice

Periciliary fluid balance is maintained by the coordination of sodium and chloride channels in the apical membranes of the airways. In the absence of the cystic fibrosis transmembrane regulator (CFTR), chloride secretion is diminished and sodium reabsorption exaggerated. ClC-2, a pH- and voltage-dep...

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Hlavní autoři: MacDonald, Kelvin D., McKenzie, Karen R., Henderson, Mark J., Hawkins, Charles E., Vij, Neeraj, Zeitlin, Pamela L.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Physiological Society 2008
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2584880/
https://ncbi.nlm.nih.gov/pubmed/18805957
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.90221.2008
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