Selective estrogen receptor-α and estrogen receptor-β agonists rapidly decrease pulmonary artery vasoconstriction by a nitric oxide-dependent mechanism

Both endogenous and exogenous estrogen decrease pulmonary artery (PA) vasoconstriction. Whether these effects are mediated via estrogen receptor (ER)-α or ER-β, and whether the contribution of ERs is stimulus-dependent, remains unknown. We hypothesized that administration of the selective ER-α agoni...

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Hlavní autoři: Lahm, Tim, Crisostomo, Paul R., Markel, Troy A., Wang, Meijing, Wang, Yue, Tan, Jiangning, Meldrum, Daniel R.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Physiological Society 2008
Témata:
Receptors and Signaling Pathways
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2584849/
https://ncbi.nlm.nih.gov/pubmed/18832085
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpregu.90667.2008
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