Estrogen receptor β mediates increased activation of PI3K/Akt signaling and improved myocardial function in female hearts following acute ischemia

Females have a lower incidence of heart failure and improved survival after myocardial ischemia-reperfusion (I/R) compared with males. Although estrogen-suppressed cardiomyocyte apoptosis may be mediated through the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt) pathway, it is unclear w...

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Detalhes bibliográficos
Main Authors: Wang, Meijing, Wang, Yue, Weil, Brent, Abarbanell, Aaron, Herrmann, Jeremy, Tan, Jiangning, Kelly, Megan, Meldrum, Daniel R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2009
Assuntos:
Receptors and Signaling Pathways
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2698598/
https://ncbi.nlm.nih.gov/pubmed/19211725
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpregu.00045.2009
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