Limited effects of dietary curcumin on Th-1 driven colitis in IL-10 deficient mice suggest an IL-10-dependent mechanism of protection

Curcumin (diferulolylmethane) demonstrates profound anti-inflammatory effects in intestinal epithelial cells (IEC) and in immune cells in vitro and exhibits a protective role in rodent models of chemically induced colitis, with its presumed primary mechanism of action via inhibition of NF-κB. Althou...

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Detalles Bibliográficos
Main Authors: Larmonier, C. B., Uno, J. K., Lee, Kang-Moon, Karrasch, T., Laubitz, D., Thurston, R., Midura-Kiela, M. T., Ghishan, F. K., Sartor, R. B., Jobin, C., Kiela, P. R.
Formato: Artigo
Idioma:Inglês
Publicado: American Physiological Society 2008
Assuntos:
Inflammation/Immunity/Mediators
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2584828/
https://ncbi.nlm.nih.gov/pubmed/18818316
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.90365.2008
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