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Structural Basis of Human PXR Activation by the Hops Constituent Colupulone
Hops extracts are used to alleviate menopausal symptoms and as an alternative to hormone replacement therapy, but can produce potentially harmful drug-drug interactions. The nuclear xenobiotic receptor PXR is promiscuously activated by a range of structurally distinct chemicals. It has a key role in...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2584763/ https://ncbi.nlm.nih.gov/pubmed/18768384 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.108.050732 |
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