The G-protein-coupled receptor kinase 5 inhibits NFκB transcriptional activity by inducing nuclear accumulation of IκBα

G-protein-coupled receptor (GPCR) kinases, GRKs, are known as serine/threonine kinases that regulate GPCR signaling, but recent findings propose functions for these kinases besides receptor desensitization. Indeed, GRK5 can translocate to the nucleus by means of a nuclear localization sequence, sugg...

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Detalhes bibliográficos
Main Authors: Sorriento, Daniela, Ciccarelli, Michele, Santulli, Gaetano, Campanile, Alfonso, Altobelli, Giovanna Giuseppina, Cimini, Vincenzo, Galasso, Gennaro, Astone, Dalila, Piscione, Federico, Pastore, Lucio, Trimarco, Bruno, Iaccarino, Guido
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2008
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2584738/
https://ncbi.nlm.nih.gov/pubmed/19008357
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0804446105
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