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High tolerance for ionizable residues in the hydrophobic interior of proteins

Internal ionizable groups are quite rare in water-soluble globular proteins. Presumably, this reflects the incompatibility between charges and the hydrophobic environment in the protein interior. Here we show that proteins can have an inherently high tolerance for internal ionizable groups. The 25 i...

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Bibliografski detalji
Glavni autori: Isom, Daniel G., Cannon, Brian R., Castañeda, Carlos A., Robinson, Aaron, García-Moreno E., Bertrand
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2008
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2584708/
https://ncbi.nlm.nih.gov/pubmed/19004768
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0805113105
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