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Structural and thermodynamic consequences of burial of an artificial ion pair in the hydrophobic interior of a protein

An artificial charge pair buried in the hydrophobic core of staphylococcal nuclease was engineered by making the V23E and L36K substitutions. Buried individually, Glu-23 and Lys-36 both titrate with pK(a) values near 7. When buried together their pK(a) values appear to be normal. The ionizable moiet...

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Bibliografiska uppgifter
Huvudupphovsmän: Robinson, Aaron C., Castañeda, Carlos A., Schlessman, Jamie L., García-Moreno E., Bertrand
Materialtyp: Artigo
Språk:Inglês
Publicerad: National Academy of Sciences 2014
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4136602/
https://ncbi.nlm.nih.gov/pubmed/25074910
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1402900111
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