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Structural and thermodynamic consequences of burial of an artificial ion pair in the hydrophobic interior of a protein
An artificial charge pair buried in the hydrophobic core of staphylococcal nuclease was engineered by making the V23E and L36K substitutions. Buried individually, Glu-23 and Lys-36 both titrate with pK(a) values near 7. When buried together their pK(a) values appear to be normal. The ionizable moiet...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4136602/ https://ncbi.nlm.nih.gov/pubmed/25074910 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1402900111 |
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