d-β-Hydroxybutyrate protects neurons in models of Alzheimer's and Parkinson's disease

The heroin analogue 1-methyl-4-phenylpyridinium, MPP(+), both in vitro and in vivo, produces death of dopaminergic substantia nigral cells by inhibiting the mitochondrial NADH dehydrogenase multienzyme complex, producing a syndrome indistinguishable from Parkinson's disease. Similarly, a fragme...

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Bibliographische Detailangaben
Hauptverfasser: Kashiwaya, Yoshihiro, Takeshima, Takao, Mori, Nozomi, Nakashima, Kenji, Clarke, Kieran, Veech, Richard L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The National Academy of Sciences 2000
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC25847/
https://ncbi.nlm.nih.gov/pubmed/10805800
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