Asymmetric Synthesis of 2,3-Dihydro-2-arylquinazolin-4-ones: Methodology and Application to a Potent Fluorescent Tubulin Inhibitor with Anticancer Activity

For several decades the 2,3-dihydroquinazolinone (DHQZ) heterocycle has been known to possess a variety of important biological and medicinal properties. Despite the many interesting facets of these molecules, synthetic access to nonracemic DHQZ analogues has remained elusive. Herein, we disclose a...

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Detalhes bibliográficos
Main Authors: Chinigo, Gary M., Paige, Mikell, Grindrod, Scott, Hamel, Ernest, Dakshanamurthy, Sivanesan, Chruszcz, Maksymilian, Minor, Wladek, Brown, Milton L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2584442/
https://ncbi.nlm.nih.gov/pubmed/18610995
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm800271c
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