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First Evidence of Genetic Association Between AKT2 and Polycystic Ovary Syndrome

OBJECTIVE—Insulin resistance has been reported in up to 70% of women with polycystic ovary syndrome (PCOS). Physiologic and genetic data currently implicate post–insulin receptor signaling defects in substrates such as glycogen synthase kinase 3β (GSK3β). The AKT2 gene was chosen as a candidate for...

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Main Authors: Goodarzi, Mark O., Jones, Michelle R., Chen, Yii-Der I., Azziz, Ricardo
פורמט: Artigo
שפה:Inglês
יצא לאור: American Diabetes Association 2008
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC2584182/
https://ncbi.nlm.nih.gov/pubmed/18768676
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/dc08-0532
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