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First Evidence of Genetic Association Between AKT2 and Polycystic Ovary Syndrome

OBJECTIVE—Insulin resistance has been reported in up to 70% of women with polycystic ovary syndrome (PCOS). Physiologic and genetic data currently implicate post–insulin receptor signaling defects in substrates such as glycogen synthase kinase 3β (GSK3β). The AKT2 gene was chosen as a candidate for...

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Detalhes bibliográficos
Main Authors: Goodarzi, Mark O., Jones, Michelle R., Chen, Yii-Der I., Azziz, Ricardo
Formato: Artigo
Idioma:Inglês
Publicado em: American Diabetes Association 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2584182/
https://ncbi.nlm.nih.gov/pubmed/18768676
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/dc08-0532
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