Combination Therapy With Glucagon-Like Peptide-1 and Gastrin Restores Normoglycemia in Diabetic NOD Mice

OBJECTIVE—Glucagon-like peptide-1 (GLP-1) and gastrin promote pancreatic β-cell function, survival, and growth. Here, we investigated whether GLP-1 and gastrin can restore the β-cell mass and reverse hyperglycemia in NOD mice with autoimmune diabetes. RESEARCH DESIGN AND METHODS—Acutely diabetic NOD...

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Hauptverfasser: Suarez-Pinzon, Wilma L., Power, Robert F., Yan, Yanhua, Wasserfall, Clive, Atkinson, Mark, Rabinovitch, Alex
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Diabetes Association 2008
Schlagworte:
Islet Studies
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2584134/
https://ncbi.nlm.nih.gov/pubmed/18835930
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db08-0688
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