Fatty Acid Synthase Inhibitors Modulate Energy Balance via Mammalian Target of Rapamycin Complex 1 Signaling in the Central Nervous System

OBJECTIVE—Evidence links the hypothalamic fatty acid synthase (FAS) pathway to the regulation of food intake and body weight. This includes pharmacological inhibitors that potently reduce feeding and body weight. The mammalian target of rapamycin (mTOR) is an intracellular fuel sensor whose activity...

Full description

Saved in:
Bibliographic Details
Main Authors: Proulx, Karine, Cota, Daniela, Woods, Stephen C., Seeley, Randy J.
Format: Artigo
Language:Inglês
Published: American Diabetes Association 2008
Subjects:
Obesity Studies
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2584128/
https://ncbi.nlm.nih.gov/pubmed/18776140
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db07-1690
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items