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Fatty Acid Synthase Inhibitors Modulate Energy Balance via Mammalian Target of Rapamycin Complex 1 Signaling in the Central Nervous System

OBJECTIVE—Evidence links the hypothalamic fatty acid synthase (FAS) pathway to the regulation of food intake and body weight. This includes pharmacological inhibitors that potently reduce feeding and body weight. The mammalian target of rapamycin (mTOR) is an intracellular fuel sensor whose activity...

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Bibliografiske detaljer
Main Authors: Proulx, Karine, Cota, Daniela, Woods, Stephen C., Seeley, Randy J.
Format: Artigo
Sprog:Inglês
Udgivet: American Diabetes Association 2008
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2584128/
https://ncbi.nlm.nih.gov/pubmed/18776140
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db07-1690
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