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Fatty Acid Synthase Inhibitors Modulate Energy Balance via Mammalian Target of Rapamycin Complex 1 Signaling in the Central Nervous System

OBJECTIVE—Evidence links the hypothalamic fatty acid synthase (FAS) pathway to the regulation of food intake and body weight. This includes pharmacological inhibitors that potently reduce feeding and body weight. The mammalian target of rapamycin (mTOR) is an intracellular fuel sensor whose activity...

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書誌詳細
主要な著者: Proulx, Karine, Cota, Daniela, Woods, Stephen C., Seeley, Randy J.
フォーマット: Artigo
言語:Inglês
出版事項: American Diabetes Association 2008
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2584128/
https://ncbi.nlm.nih.gov/pubmed/18776140
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db07-1690
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